Pharmacologic targeting of drug-induced enhancers
نویسندگان
چکیده
منابع مشابه
Pharmacologic targeting of drug-induced enhancers
In contrast to acquired resistance to targeted therapeutics via genomic changes, adaptive resistance in cancer involves rapid cellular reprogramming at a nongenomic level. In triple negative breast cancer (TNBC) we have recently described robust transcriptional adaptation to MEK inhibition (MEKi) by the FDA-approved MEK inhibitor, trametinib, in both TNBC patients and preclinical models [1]. Th...
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Drug discovery and drug delivery are two main aspects for treatment of a variety of disorders. However, the real bottleneck associated with systemic drug administration is the lack of target-specific affinity toward a pathological site, resulting in systemic toxicity and innumerable other side effects as well as higher dosage requirement for efficacy. An attractive strategy to increase the ther...
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The modular DNA recognition code of the transcription-activator-like effectors (TALEs) from plant pathogenic bacterial genus Xanthomonas provides a powerful genetic tool to create designer transcription factors (dTFs) targeting specific DNA sequences for manipulating gene expression. Previous studies have suggested critical roles of enhancers in gene regulation and reprogramming. Here, we repor...
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ژورنال
عنوان ژورنال: Oncoscience
سال: 2017
ISSN: 2331-4737
DOI: 10.18632/oncoscience.354